The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins.
نویسندگان
چکیده
The heat shock protein Hsp90 is essential for uptake of the binary actin ADP-ribosylating toxins Clostridium perfringens iota-toxin and Clostridium difficile transferase into eukaryotic cells. Inhibition of Hsp90 by its specific inhibitor radicicol delayed intoxication of Vero cells by these toxins. A common Hsp90-dependent mechanism for their translocation is discussed.
منابع مشابه
Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile
26 Some hypervirulent strains of Clostridium difficile produce the binary actin-ADP-ribosylating 27 toxin CDT in addition to the Rho-glucosylating toxins A and B. It has been suggested that the 28 presence of CDT increases the severity of the C. difficile-associated diseases including 29 pseudomembranous colitis. CDT contains a binding and translocation component CDTb, which 30 mediates the tra...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 72 5 شماره
صفحات -
تاریخ انتشار 2004